Sacubitril Hemicalcium Salt Powder

Sacubitril hemicalcium salt (CAS: 1369773-39-6), also known as AHU-377 hemicalcium salt, is a core high-purity pharmaceutical intermediate and a key neprilysin (NEP) inhibitor raw material for the synthesis of the cardiovascular innovative drug LCZ696 (Entresto) . As a professional Chinese API manufacturer, we adopt closed-loop chemical synthesis process and strict raw material screening mechanism: all upstream raw materials are selected from domestic and international certified chemical base manufacturers, with fixed raw material supply chains and traceable source reports, effectively avoiding impurity introduction in the synthesis link.
Product basic properties: Our industrial high-grade Sacubitril hemicalcium salt is a white to off-white crystalline powder with uniform color, no agglomeration, and no visible impurities. The mainstream industrial specifications are 99%. The product has stable chemical properties, an accurate molecular weight (861.04), and a standardized molecular formula, which fully meets the requirements of pharmaceutical synthesis and scientific research experiments.

High Purity & Chiral Stability: The low impurity content effectively avoids side reactions in cardiovascular drug synthesis, improves the finished drug yield and purity, and ensures the stability of drug efficacy . The internal molecular structure is stable, no decomposition or deterioration occurs during conventional production and storage, solving the problem of unstable activity of low-purity products.
Excellent Solubility & Process Adaptability: The product has excellent DMSO solubility with clear and transparent dissolved solution and no suspended impurities, which is highly compatible with the mainstream synthesis process of LCZ696 cardiovascular drugs. It can be efficiently fused with valsartan raw materials in the reaction link, shorten the synthesis cycle of finished drugs, and reduce industrial production costs .
Strict Safety & Compliance: Adopt full-process closed synthesis and impurity removal technology, with extremely low heavy metal and harmful residue content. All indicators comply with USP, EP and global pharmaceutical industrial production standards. Complete batch detection data ensures zero safety risks in downstream pharmaceutical finished products, suitable for high-standard export pharmaceutical production.
Batch Consistency & Scalability: Independent industrial production workshop and standardized assembly line realize large-scale stable production. The core indicators of each batch of products have almost zero fluctuation, avoiding the problem of unstable finished drug quality caused by batch difference of raw materials. It can support long-term stable bulk supply for pharmaceutical factories.
Long Shelf Life & Environmental Adaptability: Optimized calcium salt crystallization process improves product antioxidant and moisture-proof properties. Under standard sealed storage conditions, the shelf life is up to 24 months, which is longer than the industry average, reducing raw material loss and inventory cost for downstream manufacturers.

Cardiovascular Innovative Drug Production : It is the key synthetic raw material of LCZ696 (Entresto), a first-line drug for clinical treatment of chronic heart failure and primary hypertension. It exerts therapeutic effect by inhibiting neprilysin activity, and is widely used in the industrial production of cardiovascular innovative drugs by major pharmaceutical enterprises .
Biomedical Scientific Research: As a high-efficiency NEP inhibitor, it is used in laboratory research on cardiovascular disease mechanism, drug efficacy verification and new drug development by global medical research institutions and university laboratories, and has been cited in many top medical journals such as Nature Medicine .
Pharmaceutical Raw Material Customized Synthesis: Provide high-purity raw material support for customized development of new cardiovascular generic drugs and modified drugs, meeting the personalized R&D and production needs of pharmaceutical enterprises.
Pharmaceutical Detection & Standard Substance: High-purity finished products can be used as standard reference substances for pharmaceutical testing institutions to detect the purity and quality of finished cardiovascular drugs, supporting pharmaceutical quality supervision and testing work.

European Pharmaceutical Factory Long-term Supply Case: Cooperate with a European medium-sized innovative pharmaceutical enterprise for 3 consecutive years, providing 99% high-purity Sacubitril hemicalcium salt in bulk all year round. The product batch stability and compliance indicators fully meet EU pharmaceutical production standards, helping the enterprise complete the mass production of heart failure drugs and pass EU drug quality certification successfully.
American Biomedical R&D Institution Cooperation Case: Provide customized high-chiral-purity products for an American medical research institute, supporting its new cardiovascular drug mechanism research and pre-clinical experimental projects. The product's ultra-low impurity and stable activity ensure the accuracy of experimental data, and become the designated long-term raw material supplier of the institution.

Q: What are the packaging and storage requirements of the product?
A: Conventional packaging is 1g/5g/10g/100g/1kg aluminum foil bag and cardboard drum packaging; supports customized packaging. The product needs to be stored in a sealed, dry, dark environment at -20℃, with a shelf life of 24 months under standard storage conditions.
Q: Do you support sample testing and small-batch trial orders?
A: We support free sample testing for customers and accept small-batch trial orders and large-batch bulk orders.
Q: What is the delivery cycle and logistics mode?
A: Conventional spot orders can be delivered within 3-5 working days, and customized bulk orders can be delivered within 7-15 working days. We support international express, sea freight and air freight, with complete customs clearance and safety certification documents, ensuring safe and smooth delivery to global countries and regions.

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